Learning 3D biophysical cell properties from 2D images and cell-population statistics
Abstract: Inferring 3D cellular properties from 2D microscopy is difficult when a reference instrument reports only population statistics rather than labels for individual cells. Here we develop a population-supervised framework that maps single 2D red-cell images to latent biophysical quantities and aggregates them to mean corpuscular volume, red-cell distribution width and mean corpuscular haemoglobin. The model combines shared local inference, a biophysically structured decoder for volume and haemoglobin, learned instance weighting and device-specific calibration. We formalise conditions under which aggregate observations identify restricted instance predictors, show why population agreement does not by itself identify single-cell properties or 3D geometry, and derive the dispersion penalty induced by subset mean matching. The development dataset comprises 390 specimens and 1,105 acquisitions across six devices, with reported Pearson correlations of 0.86--0.98 against a Sysmex analyser. The framework provides a testable route from 2D images and population supervision to 3D cellular biophysics without claiming explicit 3D reconstruction.
Submission history
Access Paper:
Current browse context:
References & Citations
BibTeX formatted citation
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website.
Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them.
Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs .
Verified source · arXiv.org
Reported by arXiv.org. Open the original for full media and formatting.
More in Research
All newsDidactic knowledge or Clinical Cases? How Data Types Shape Medical Large Language Models
Medical large language models are commonly trained on mixtures of didactic data (e.g., textbooks) and clinical data (e.g., patient records), yet how these data types differentially shape model capabilities remains unclear. We address this issue with token-matched experiments that vary the didactic-to-clinical ratio and analyze how data composition affects performance, capability profiles, and error patterns across knowledge-intensive and clinic-oriented tasks. We uncover an asymmetric transfer across task types: clinical data improves clinic-oriented tasks while remaining competitive on knowl…
Read at arXiv cs.AIEvidenT: Building Trustworthy Enterprise Assistants through Evidence Groundedness and Traceability
Enterprise AI assistants must produce responses that are verifiable and traceable to source evidence. However, retrieval augmented generation (RAG) over heterogeneous enterprise data can suffer from citation drift, unsupported content, and weak source traceability. We present EvidenT (T = Trust + Transparency + Traceability), a lightweight pipeline that verifies extracted evidence against retrieved documents before answer generation, without model retraining. EvidenT combines structured passage extraction with deterministic lexical alignment to filter unsupported content, correct citation dri…
Read at arXiv cs.AISocial Influence and the Allocation of Scientific Attention in AI Populations
AI systems are becoming participants in the evaluation and use of scientific research. They encounter citation counts, download statistics and lists of popular articles developed around human readers, but the collective consequences of these signals for artificial readers remain uncertain. This paper adapts the Music Lab design to a market for academic attention. In the first experiment, 1,000 AI agents choose papers from the titles and abstracts of all 114 regular research articles published in the American Economic Review in 2025. The experiment has five independent-choice communities and f…
Read at arXiv cs.AIPAANI : On Device Visual Evidence Fusion and Explainable Guidance for River Robot Simulation
Mobile river monitoring robots must interpret obstacles and water boundaries that geographic waypoints alone cannot describe. On resource constrained platforms, converting imperfect visual predictions into timely and inspectable guidance is a distinct challenge. An object label or steering command does not explain which evidence supports a decision or when that evidence is unreliable. We present PAANI, an on-device perception to guidance architecture that combines a project trained YOLO11n detector and a custom MobileNetV3 Small semantic segmenter with timestamp aligned evidence fusion on Ard…
Read at arXiv cs.AI